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【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【騰訊  】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

利用小鼠朊病毒疾病的模型，研究人員確定這些新生神經元產生的時間進程，以及它們如何融入大腦回路中。雖然這種自我修復機制能夠有效維持疾病早期和中間階段的神經功能，但是在更高級的階段中卻無法維持。這突出一個為了保護有益增強神經發(fā)生的影響的潛在干預治療的時間窗口。
戈麥斯 - 尼古拉博士說：“這項研究顯示，大腦的潛能有助于協(xié)調自我修復反應。繼續(xù)這方面的研究開辟新的途徑，確定哪些特殊信號有助于促進神經發(fā)生反應的增加，專注于神經發(fā)生作為一種促進缺失神經元再生的治療方法。”
這項研究發(fā)表于《大腦》雜志上，由歐盟第七框架計劃和醫(yī)學研究理事會(MRC)資助。
已知由大腦中的海馬體協(xié)調學習和記憶能力。在誕生之前，大腦的大部分已經發(fā)育完畢。此后還要經歷兩個發(fā)育高峰時期，一個是兒童期，一個是青春期，這兩個階段大腦發(fā)育快速。在過去20年間，研究證實，成人的神經再生主要發(fā)生在海馬體中。
該研究通過一個動物模型發(fā)現(xiàn)，核受體TLX基因過量表達時，試驗對象聰明且學習起來更快，另外所獲得的信息能持續(xù)得更持久。

Using a model of mouse prion disease, researchers determine the timing of these newborn neurons and how they integrate into the brain's circuitry. Although this self-healing mechanism can effectively maintain the neurological function of the early and middle stages of the disease, it can not be maintained at a more advanced stage. This highlights a time window for potential interventions to protect the beneficial effects of neurogenesis.
Dr. Gomez-Nicola said: "This study shows that the brain's potential helps to coordinate self-healing reactions." Continuing studies in this area have opened up new avenues to determine which particular signals contribute to promoting an increased neurogenic response , Which focuses on neurogenesis as a treatment for de novo neuron regeneration. "
The study, published in the journal Brain, is funded by the EU's Seventh Framework Program and the Medical Research Council (MRC).
It is known that the hippocampus in the brain coordinates the learning and memory abilities. Before birth, much of the brain has been developed. There are two more developmental periods to follow, one in childhood and one in adolescence, during which time the brain develops rapidly. In the past 20 years, studies have confirmed that adult nerve regeneration occurs mainly in the hippocampus.
The study, based on an animal model, found that when the nuclear receptor TLX gene is overexpressed, subjects are smart and learn faster, and the information they receive lasts longer.